World Scientific Publishers

Cardiac Drug Safety

A Bench to Bedside Approach

Matthew J Killeen (University of Cambridge, UK)

Februar 2012 · 188 S. · Geb. · 9789814317450 · GBP £ 48,00

Extensive research over the past decade has shed light on the root causes of arrhythmias that are triggered by medications and has helped drive, and optimize, drug safety testing.However, current cardiac safety platforms have several limitations and there remains a pressing unmet need to improve the predictive power of today’s drug safety tests. Fundamental to addressing the problem of drug-induced arrhythmias, and to reducing the impact of this safety signal on drug development, is a complete understanding of how these events may arise, what cardiac safety tests are currently used, and what opportunities there are to enhance patient safety and reduce the risk of detecting cardiac toxicity in later stages of product commercialization. By introducing the reader to these core concepts, this book deliverskey insight into the increasingly important and dynamic field of cardiac safety.

High Performance Liquid Chromatography Fingerprinting Technology of the Commonly-used Traditional Chinese Medicine Herbs

Baochang Cai (Nanjing University of Chinese Medicine), Seng Poon Ong (Temasek Polytechnic, Singapore), & Xunhong Liu (Nanjing University of Chinese Medicine)

Feburar 2012 · 384S. · Geb. · 9789814291095 · GBP £ 78,00

This book provides a comprehensive and up-to-date account of the HPLC technology and fingerprints of commonly-used Chinese herbs. It contains HPLC fingerprints of over 40 traditional Chinese medicinal herbs and details of their sources, production and quality control. The book provides a practical review of the techniques, relevant materials, and the particular demands for using HPLC in traditional Chinese medicinal herb applications. It also covers HPLC methods used to analyze the herbs.

High-performance liquid chromatography (HPLC) is increasingly used in the field of traditional Chinese medicine for obtaining fingerprints of Chinese medicinal herbs. Advantages such as high speed, high resolution, high sensitivity, stability, accuracy, and automation make it one of the leading techniques used for quality control, standardization of planting, and new drug development in traditional Chinese medicine.

To date, no other books on HPLC fingerprints of traditional Chinese medicinal herbs have been published in English. This is the first book in English devoted to providing readers with state-of-the-art information on HPLC applied in the analysis of traditional Chinese medicinal herbs.